CBD oil for Parkinson’s disease works. A number of patients suffering from this illness attested that it helps improves their condition.
Are you looking for CBD oil for Parkinson’s disease (PD)? Want to know the highly recommended brands?
If you are interested in Parkinson’s disease and CBD oil, you will find answers here. This content is dedicated to helping you understand CBD and Parkinson’s disease and see if CBD oil can really help with PD.
PD is a pretty common neurodegenerative disease of the nervous central system. In fact, nearly one million is predicted to be living with PD in the U.S. by 2020 which is more than the combined number of people diagnosed with multiple sclerosis, muscular dystrophy, and Lou Gehrig’s disease.
Approximately 60,000 Americans are diagnosed with this condition each year and more than 10 million worldwide are living with PD. The incidence of Parkinson’s disease increases with age. But an estimated percent of people with PD are diagnosed before age 50.
For those who are suffering from this condition and are willing to try an alternative medication, this page is for you! You will discover here if Parkinson’s disease and CBD oil can work together.
Here is a list of the best CBD oil for Parkinson’s disease.
Contents [hide]
| Products | Shop now | Price | Rating | THC content | Strengths Available |
|---|---|---|---|---|---|
Endoca | Shop Here | $28.99 | 4.9/5 | Yes, minimal | 300 mg /1500 mg |
PureKana | Shop Here | $40 | 4.8/5 | No | 300 mg/ 600 mg/ 1,000 mg |
Charlotte’s Web | Shop Here | $39.99 | 5.0/5 | Yes, very minimal | Full (base strength) / Extra (2x stronger than full) / (8x stronger than full) |
CBDfx | Shop Here | $59.99 | 4.5/5 | Yes, minimal | 60 mg/ 120 mg/ 300 mg/ 500 mg/ 1000 mg |
CBDPure | Shop Here | $29.99 | 4.3/5 | Yes, minimal | 100 mg/ 300 mg / 600 mg |
Which CBD Oil is Best for Parkinson’s disease
CBD oil used for Parkinson’s disease is growing in popularity. Many are convinced that CBD and Parkinson’s disease can work together.
There are numerous studies supporting the positive effects of cannabinoid to PD. So, pretty sure you are here to find the best CBD oil used for Parkinson’s disease. Without further ado, let’s get started!
1. Endoca CBD Oil Review
Endoca CBD Hemp Oil is made of concentrated, ultra-pure and premium quality. For those looking forward to buying the most potent CBD oil, this is highly recommended.
Endoca is five-star approved CBD oil, so you can rely on its safety and effectiveness. Also, what I really loved about this CBD oil is its taste because it has a milder flavor. CBD oils are not easy to tolerate, it tastes like grass.
Endoca CBD oils are made with 100% organic hemp. It is vegan, gluten-free and non-GMO.
Endoca stays true to the wisdom of nature. They interfere as little as possible with the plant’s natural state to deliver the best results as possible. In this way, you will get the benefits of the hemp plant just as nature intended.
Endoca is also constantly striving to improve its production method by employing a team of scientists, herbalists and nutritionists to formulate its organic hemp oil extracts to the highest standards.
Endoca is manufactured to help you with your health and wellness. You can bank on this when it comes to PD. The good thing with this is that aside from improving PD, it also helps you eat, sleep and relax to live healthier and happier lives.
Considering the products’ quality, the satisfying results it delivers and the great customer service, we highly recommend Endoca.
Pros
- Highly-concentrated CBD oil
- Very effective in reducing or healing pain
- Easy to order
- Orders can be tracked on the website
- Fast shipping and delivery
- Excellent support
Cons
- Results vary
- Expensive
2. PureKana CBD Oil Review
PureKana is a natural dietary supplement for improving your quality of life. It is organic, non-GMO industrial hemp that is cultivated in Denmark. It’s also among the most popular brands when it comes to CBD oils.
The good thing with this brand is it offers a variety of CBD oil products to cater to whatever your preference is. They have capsules and other edibles. If like me, you are very particular with taste, I recommend that you try their Vanilla and Mint variants because it smells and tastes better than Natural.
The CBD oils are available in three strengths 300mg, 600mg, and 1,000mg. Whatever strength you get, start with a lower dosage and work your way up.
This CBD oil is very effective and very comfortable to use. It includes a dropper with measurement to make it easy and convenient for you to use it.
PureKana produces high-quality products that you can trust. The brand is dedicated to giving you the best experience from ordering to enjoying the best result after using their product.
Pros
- Tastes good (mint)
- Includes tasty treats for dogs
- Available in different dosages
- Works incredibly well in reducing pain
- Easy to use because the dropper has measurement
Cons
- Pricey
- Results vary
- You have to get the one with a higher dosage to see results
- Sometimes delivery takes too long
3. Charlotte’s Web CBD Oil Review
Charlotte’s Web CBD oil another popular brand especially for seizures and epilepsy. PD patients experience tremors in the hand that slowly spreads throughout the body causing slowed voluntary motion, rigid muscles, stooped posture, loss of involuntary movements and speech changes. For this reason, Charlotte’s Web can help because the brand also works for PD.
Charlotte’s Web’s effectiveness is undeniable. In fact, this has been named after a little girl who suffered from seizure since birth. She was wheelchair-bound by 3 and couldn’t eat or talk. When she was 5, the doctors told her parents that they have already exhausted all the medication options and that there’s nothing they could do anymore.
That little girl survived thanks to CBD oil. The number of her seizures significantly decreased and her condition greatly improved. Today, she’s able to engage in normal childhood activities.
Charlotte’s Web can deliver the same result for PD. This brand is more than just CBD. It also offers naturally-occurring phytocannabinoids, terpenes, flavonoids and more in every serving to support you from daily stress, keep you calm and enable you to enjoy a healthy recovery from exercise. This CBD oil is a good addition to your daily supplement.
Pros
- Works great for seizures
- Has easy to use dropper
- Trusted company
- Very consistent
- Its mint chocolate flavor tastes fine
- Eliminates pain and rigidness associated with multiple sclerosis
- Lab results available upon request
Cons
- Expensive
- Slow shipping
- Difficult to dose
- Unresponsive customer service
5. CBDfx CBD Oil Review
CBDfx CBD oil is one of the most-trusted CBD oil brands. Its quality is visible at first sight by looking at its color – light gold, which indicates the quality of filtering use to extract the CBD oil.
Another thing I appreciate from this brand is the taste and texture of the product. It is natural and has no flavorings but it’s not as awful as the other brands. It actually tastes good and doesn’t have any unpleasant aftertaste.
The product is packed in a clear bottle that allows you to examine its color and purity at first glance. Most products usually come in amber or colored bottles and I personally prefer CBDfx’s bottles.
CBDfx works well in making you feel and look good. It improves the quality of sleep, helps you relax and even helps in weight loss.
When I used this CBD oil, my life was transformed. It’s more peaceful, relaxing and happier. I’m confident that this can help with PD because this also works for tremors. I highly recommend this.
Pros
- Good packaging
- Effectively improves sleep
- Help you relax
- Aids in weight loss
- Detailed instructions in plain sight
- Tastes natural without the unpleasant aftertaste
- Has sturdy dropper
Cons
- Expensive
6. CBDPure CBD Oil Review
This brand is derived from certified organic-standards industrial hemp. It is high-quality and safe as the hemp used are chemical-free and pesticide-free. This is the most powerful and beneficial CBD that you’ll find on the market as it contains all-natural cannabidiol (CBD), terpenes and other cannabinoids.
In addition, the brand is dedicated to giving you the best CBD oil so they implement strict quality control. Their products are tested by a third-party lab and rest-assured that you’re free from harm when using this.
Also, you do not need to worry about its THC content because it’s actually too low. This product is not addicting and you will not feel high after using it.
CBDPure is just like any other normal CBD oil, it has an earthy smell and has the normal traditional hemp oil taste. The good thing is that even if it tastes like that, it wasn’t so bad. Some brands are worse.
I’m also very happy with this brand because they themselves are very confident of what they offer. In fact, they backed their products with 90-day money-back guarantee giving you the option to try it worry-free. So, I suggest that you check this out.
Pros
- Organic CBD oil
- Uses CO2 extraction to process CBD
- All products are quality tested by independent third-party
- 90-day money back guarantee
Cons
- Expensive
- Doesn’t ship in some states and internationally
Does CBD Oil Work for Parkinson’s disease
Will CBD oil help with Parkinson’s disease? There are a number of positive reviews about CBD oil working to improve patients with PD. This wasn’t actually surprising considering the number of miracles CBD can do to one’s health.
In the past years, there has been an increase in the number of states across America taking note of cannabis and cannabinoids as a potential therapy for different health conditions including Diabetes, Alzheimer’s, Multiple Sclerosis, Crohn’s disease, Anxiety, Depression, sleep disorder and Parkinson’s disease to name a few.
According to Marijuana Break, science has suggested that CBD oil could help Parkinson’s disease in a big way. Most of the states with a medical marijuana program include PD on the list of qualifying medical conditions.
Marijuana has been referenced as a treatment for PD as far back as the 19th century where it was mentioned in the authoritative clinical volume “Manual of diseases of the Nervous System.”
There is a mixed opinion when it comes to marijuana’s effect on CBD oil. Most doctors do not support the study results because they do not meet the minimum research standards but a number of researches have positive claims about CBD oil and Parkinson’s disease.
Here are some of the studies supporting CBD oil’s positive impact on patients with PD.
- A study published in 2014 by scientists from the Department of Neurology in Tel Aviv, Israel examined how cannabis could treat a range of motor and non-motor symptoms in Parkinson’s patients. The study looked at 22 subjects suffering from PD mainly in the following areas:
- Unified Parkinson’s Disease Rating Scale.
- Visual Analog Scale.
- Present Pain Intensity Scale.
- Short-form McGill Pain Questionnaire.
- Medical Cannabis Survey National Drug and Alcohol Research Centre Questionnaire.
The study found that it significantly improves the mean total motor score on the Unified Parkinson Disease Rating Score dropping from 33.1 to 23.1 after smoking cannabis. In addition, it improves tremors and rigidity.
That’s not all, it also improves pain and sleep scores for all patients suggesting that marijuana can be particularly useful for treatment for Parkinson’s disease.
- Another study in 2014 examined the effect of cannabidiol in the treatment of patients with PD disease. The research involved 119 patients who were assigned to three groups of seven subjects each who were treated with placebo, cannabidiol (CBD) 75 mg/day or CBD 300 mg/day.
One week before the trial and in the last week of treatment participants were assessed with respect to:
- motor and general symptoms score (UPDRS)
- well-being and quality of life (PDQ-39)
- possible neuroprotective effects (BDNF and H (1)-MRS)
The study didn’t find significant differences in UPDRS scores, plasma BDNF levels or H(1)-MRS measures. However, the groups treated with placebo and CBD 300 mg/day had significantly different mean total scores in the PDQ-39 (p = 0.05).
The researchers concluded the possible effects of CBD in improving quality of life measures in PD patients with no psychiatric comorbidities.
- Another study published in 2009 by the Department of Neuropsychiatry and Medical Psychology revealed that the cannabinoid could also help with onset psychosis in some Parkinson’s patients.
The study involved six outpatients with Parkinson’s disease. All of them suffered from psychosis for a minimum of three months and were administered an oral dose of CBD beginning with 150 mg a day for four weeks alongside their usual treatment.
After four weeks, the subjects’ psychotic symptoms were evaluated and the results showed a significant decrease in symptoms. All of the six patients showed improvements in their PD conditions without adverse effects. The CBD also did not worsen the motor functions the subjects.
- A 2018 study published online examined cannabidiol as a promising strategy to treat and prevent movement disorders. Movement disorders include Parkinson’s disease and dyskinesia.
The pre-clinical studies are promising with a few patients failing to detect an improvement of the motor symptoms after CBD treatment. There is a significant difference between the clinical and pre-clinical PD studies. In animals, the beneficial effects are seen when CBD is administered prior to or immediately after the manipulation that induces the PD-like symptoms, which suggests that CBDs might have a preventive role rather than therapeutic in PD.
Unfortunately, early diagnosis of PD is a challenge. PD is diagnosed subsequently to the emergence of motor symptoms that only appears up to 10 years after the beginning of neurodegeneration and the onset of non-motor symptoms. The development of diagnosis criteria to detect PD in early stages would probably expand the CBD’s applications in this disease.
- A 2004 survey of cannabis use among patients at the Prague Movements Disorder Centre in the Czech Republic revealed that CBD has positive effects on PD. Forty-five percent of the respondents reported an improvement in PD motor symptoms.
- Although most doctors don’t recommend CBD oil for PD, Dr. Bonni Goldstein admitted in her book Cannabis Revealed published in 2016 that CBD oil helped a number of his patients.
“A number of my patients with PD have reported the benefits of using different methods of delivery and different cannabinoid profiles. Some patients have found relief of tremors with inhaled THC and other have not. A few patients have found relief with high doses of CBD-rich cannabis taken sublingually. Some patients are using a combination of CBD and THC … Trial and error is needed to find what cannabinoid profile and method will work best. Starting a low-dose and titrating up is recommended, particularly with THC-rich cannabis. Unfortunately, THCV-rich varieties are not readily available,” Dr. Goldstein said.
So, does CBD oil can help people with Parkinson’s disease? Yes, it definitely can, based on the studies and testimonials mentioned above.
What Effect Does CBD Oil Have on Parkinson’s disease
How does CBD oil help Parkinson’s disease? What does CBD oil do for Parkinson’s disease?
The CBD oil effects on Parkinson’s disease could be attributed to how it activates a receptor called “GPR6.”
A poster by Zhao-Hui Song and Alyssa S. Laun at the 2017 meeting of the International Cannabinoid Research Society in Montreal revealed that CBD can activate a G-coupled protein receptor called “GPR6” that is highly expressed in the basal ganglia region of the brain.
Researchers have yet to find the primary endogenous compound that binds GPR6 so they considered this an “orphan receptor.”
It has been shown that depletion of GPR6 causes an increase of dopamine, a critical neurotransmitter in the brain. PD is associated with progressive loss of dopaminergic (dopamine-producing) neurons and consequent impairment of motor control. GPR6 can act as an “inverse agonist” to boost dopamine levels. Thus, GPR6 could have a role in the treatment of PD.
CBD Oil Dosage for Parkinson’s Disease
There is no typical dose of CBD oil for Parkinson’s disease because the dosage depends on the brand you use, the strength of the oil, your weight, and how your body responds to it.
Juan Sanchez-Ramos M.D. Ph.D. a leader in the field of movement disorders and Medical Director for the Parkinson Research Foundation told Project CBD that he encourages his patients to begin with 1:1 THC: CBD ratio product if they can get it.
In a book chapter on “Cannabinoids for the Treatment of Movement Disorders,” he and co-author Briony Catlow, Ph.D., described the dosage protocol used for various research studies that provide statistically positive results and a dosing baseline for PD.
Here’s a summary of dosing regiments from various studies compiled by Dr. Ethan Russo.
- 300 mg/day of CBD significantly improved quality of life but had no positive effect on the Unified Parkinson Disease Rating Scale. (Lotan I, 2014)
- 5 g of smoked cannabis resulted in significant improvement in tremor and bradykinesia as well as sleep. (Venderová K, 2004)
- 150 mg of CBD oil titrated up over four weeks resulted in decreased psychotic symptoms. (Chagas MH, 2014)
- 75-300 mg of oral CBD improved REM-behavior sleep disorder. (Zuardi AW, 2009)
In general, Dr. Russo suggests 2.5 mg of THC as a threshold dose for most patients without prior tolerance to its effects while 5 mg is a dose that may be clinically effective at a single administration and is generally acceptable. Meanwhile, 10 mg is a prominent dose but this may be too high for naive and even some experienced subjects.
Benefits of CBD Oil for Parkinson’s disease
Although doctors don’t recommend CBD oil for Parkinson’s disease, a number of studies support the positive effects that it delivers to PD patients who use it. Check out the list below.
Improved Sleep. CBD proved to be very effective in addressing sleep disorders which is a common side effect of Parkinson’s disease. When PD patients experience improved sleep cycle, it adds to their quality of life.
Decreased Psychosis. Psychotic symptoms develop with the progression of Parkinson’s disease where patients experience hallucinations. A small dose of CBD has been proven to reduce the occurrence of hallucinations.
Anti-Inflammatory. Sustained inflammations in the brain lead to the loss of dopamine. CBD, when used to treat brain inflammations, increases dopamine. In addition, according to research, decreased inflammations slow down the progression of Parkinson’s disease.
Neuroprotectant. PD is a neurodegenerative disease and CBD acts as a neuroprotectant and as a powerful antioxidant. Oxidative stress is believed to cause this condition.
Conclusion
Is CBD oil good for Parkinson’s disease? Based on the studies and testimonials, yes, this product can help patients with PD. It can help with inflammation, sleep disorder and psychosis that worsen the condition.
If you are interested in getting a CBD oil for Parkinson’s disease, the brands aforementioned are highly recommended. They are of good quality and they deliver the results they promised. Try this and you will surely love it.
If you need to learn more about CBD oil, feel free to check out our homepage.
References
parkinson.org/Understanding-Parkinsons/Statistics
www.marijuanabreak.com/cbd-for-parkinsons-disease
www.parkinson.org/Understanding-Parkinsons/Treatment/Medical-Marijuana
www.projectcbd.org/parkinsons-disease
www.ncbi.nlm.nih.gov/pubmed/25237116
www.ncbi.nlm.nih.gov/pmc/articles/PMC5958190
www.endoca.com/blog/cbd-and-parkinsons
www.projectcbd.org/medicine/cbd-and-parkinsons-disease
www.practicalneurology.com/2018/05/medical-marijuana-and-parkinsons-disease
www.mellomarijuana.com/2018/10/11/cbd-oil-for-parkinsons
www.nordicoil.eu/wiki/cbd-for-parkinsons-disease/#neuroprotectant
www.parkinson.org/Understanding-Parkinsons/Treatment/Medical-Marijuana
www.projectcbd.org/parkinsons-disease
www.ncbi.nlm.nih.gov/pubmed/25237116
www.ncbi.nlm.nih.gov/pmc/articles/PMC5958190
www.endoca.com/blog/cbd-and-parkinsons
www.projectcbd.org/medicine/cbd-and-parkinsons-disease
www.practicalneurology.com/2018/05/medical-marijuana-and-parkinsons-disease
www.mellomarijuana.com/2018/10/11/cbd-oil-for-parkinsons
www.nordicoil.eu/wiki/cbd-for-parkinsons-disease/#neuroprotectant
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